IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

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Department Of Biotechnology

World University root node

Organic Syntheses

Mild and selective oxidation of sulfur compounds in trifluoroethanol: Diphenyl disulfide and methyl phenyl sulfoxide: [(Disulfide, diphenyl- and benzene, (methylsulfinyl)-)]

Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5‘-end of all HIV mRNAs. Here we report the design, synthesis and in vitro activities of oligopeptoid amide and ester analogues which bind TAR RNA with high affinities. These results show that we have identified a new class of unnatural oligomers for RNA targeting.&nbsp;

Department Of Chemical Engineering

Bioconjugate Chemistry.

A New Class of RNA-Binding Oligomers:  Peptoid Amide and Ester Analogues

The oxidation of cyclohexane with molecular oxygen in the presence of isobutyraldehyde catalyzed by nanostructured iron and cobalt oxides and iron oxide supported on titania has been studied. It was found that highly dispersed transition metal oxide is more effective for oxidation than the corresponding zero-valent metal powders. Nanostructured cobalt oxide on MCM-41 is found to be efficient for catalytic aerobic epoxidation of olefins. The catalyst is reusable and gives moderate to high regio- and stereoselectivity.

Department of Ocean Engineering

Journal of the Indian Institute of Science

Studies of catalytic aerobic oxidation with nanostructured amorphous metals, alloys and metal oxides

The oxidation of cyclohexane with molecular oxygen in the presence of isobutyraldehyde catalyzed by nanostructured iron and cobalt oxides and iron oxide supported on titania has been studied. Nanostructured cobalt oxide on MCM-41 is found to be efficient for catalytic aerobic epoxidation of olefins.

Fulltext

Pure and Applied Chemistry

Nanostructured amorphous metals, alloys, and metal oxides as new catalysts for oxidation

Journal of Organic Chemistry

Facile ring opening of oxiranea with aromatic amines in fluoro alcohols

The first catalytic oxidation of trifluoromethyl carbinols has been accomplished by a novel ruthenium(II) complex using sodium periodate as an oxidant. Trifluoromethyl ketones were obtained under mild conditions and in excellent yields. (C) 2000 Elsevier Science Ltd.

Tetrahedron Letters

New catalytic oxidation of trifluoromethyl carbinols by a ruthenium(II) complex

β-Hydroxy sulfoxides were obtained in one-pot synthesis by the ring opening of oxiranes with thiols in hexafluoroisopropanol (HFIP) without any catalyst, followed by in situ oxidation under neutral conditions. The reaction is anti-selective. β-Hydroxy sulfoxides were transformed by pyrolysis in the corresponding allylic alcohols. (C) 2000 Elsevier Science Ltd.

Fluoro alcohol as reaction medium: One-pot synthesis of β-hydroxy sulfoxides from epoxides

Quantitative oxidative conversion of thiols to disulfides was effected by aqueous 30% H2O2 in trifluoroethanol at ambient temperature under neutral conditions.

Synthesis

Oxidation in fluoro alcohols: Mild and efficient preparation of disulfides from thiols

Under mild conditions (40 atm O2, 28°C, 10-15 h), an efficient aerobic oxidation of cycloalkanes to cycloalkanols can be achieved using nanostructured amorphous metals such as Fe and Co and an amorphous alloy like Fe20Ni80 as catalysts. For example, cyclohexane is oxidized to cyclohexanol with 32-41% conversion, while 1-adamantanol is formed from adamantane with 52-57% conversion.

Angewandte Chemie - International Edition

Catalytic aerobic oxidation of cycloalkanes with nanostructured amorphous metals and alloys

Catalytic β-stereoselective epoxidation of Δ5-unsaturated steroid derivatives has been effected by a novel ruthenium(II) bioxazoline complex under aerobic conditions. The reactions are regio- and stereoselective. The reaction conditions provide the corresponding 5β,6β-epoxides with high degree of stereoselectivity (88-96%) in very good yields, while oxidation of steroid derivatives with peracids leads to 5α,6α-epoxides as the major products. The overall conformation of the steroid nucleus is nearly planar in the cholesteryl ester, while it is bent at the junction between the rings A and B in the 5β,6β-epoxide. This change from pseudo-trans- to cis-stereochemistry of the A-B ring junction provides more room for the catalyst to approach from the β-face of the steroidal skeleton. © 1998 American Chemical Society.