Low molecular weight gels have relatively poor self-healing capacity compared to that of polymeric gels. Induction and tuning of the healing capacity of low molecular weight gels to achieve desired applications are thus challenging tasks. The present work describes the achievement of remarkable tunability of self-healing property for a low molecular weight hybrid gel, based on poly(aryl ether) dendron derivative (PAD). The hybrid gel has been synthesized using PAD and poly(amido amine) {PAMAM} dendrimer derivative (QPD), which are intercalated in the montmorillonite clay (MMT) layers. The self-healing of the hybrid gel (QPD-MMT-PAD) was demonstrated through experiments where the distorted gel regained the initial value of storage modulus (G′) within a few minutes. Further, the propensity of self-healing of the gel has been tuned as a function of QPD concentration. The mechanically stable QPD-MMT-PAD hybrid gel has been utilized for the adsorption of ppm level concentration of polycyclic aromatic hydrocarbons (PAHs) such as β-naphthol, pyrene, and phenenathrene from water with excellent efficiency (80-98%). © 2016 American Chemical Society.

Edamana Prasad

Department Of Chemistry

Balachandran Vivek

Aromatic hydrocarbons

Dendrimers

Gels

Molecular weight

Naphthol

Pyrene

Clay nanocomposites

DENDRIMER DERIVATIVES

LOW MOLECULAR WEIGHT

MECHANICALLY STABLE

Montmorillonite clay

Polycyclic aromatic hydrocarbons (PAHS)

SELF-HEALING PROPERTIES

VALUE OF STORAGES

Polycyclic aromatic hydrocarbons

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

Journal of Physical Chemistry B

Herein, we describe the design, synthesis and drug release kinetics of a low molecular weight gel based on an aryl ether dendron, under in vitro conditions. The first generation dendron self-assembles and forms gels, resulting in a robust three-dimensional fibrous network, to facilitate controlled release of molecules. While aryl ether dendrons are known for their enhanced self-assembling propensity, these systems have not been used for drug release studies. The self-assembled system was characterized using SEM, TEM, rheology and PXRD experiments. In vitro cytotoxicity of the dendron gel was studied and the results show that the dendron gel is biocompatible. The effect of gel leaching and the exposure time on NIH/3T3 cells is also studied. Further, the gel based on poly aryl ether dendron derivative (D1) is capable of entrapping model hydrophilic dyes and a local anaesthetic drug (prilocaine hydrochloride), where the D1 gel could effectively entrap about 1.5 mg of prilocaine hydrochloride per 5 mg of gelator. The in vitro drug release suggests that the release kinetics is inversely proportional to the gelator wt%, and the lowest release rate obtained is 1.75 min-n with 0.7 gelator wt%. The release profiles of prilocaine hydrochloride are fitted with the Peppas-Korsmeyer model, and the results depict a non-Fickian diffusion mechanism. These studies indicate that the poly aryl ether dendron based gel shows desirable characteristics and also displays promising possibilities of expanding dendron based drug delivery systems for transdermal applications. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2017.

New Journal of Chemistry

In vitro study of a glucose attached poly(aryl ether) dendron based gel as a drug carrier for a local anaesthetic

In this work, a self-healing hydrogel has been prepared using in situ polymerization of acrylic acid and acrylamide in the presence of glycogen. The hydrogel was characterized using NMR, SEM, FT-IR, rheology, and dynamic light scattering (DLS) studies. The developed hydrogel exhibits self-healing properties at neutral pH, high swelling ability, high elasticity, and excellent mechanical strength. The hydrogel exhibits modulus values (G′, Ga″) as high as 106 Pa and shows an exceptionally high degree of swelling ratio (∼3.5 × 103). Further, the polymer based hydrogel adsorbs toxic metal ions (Cd2+, Pb2+, and Hg2+) and organic dyes (methylene blue and methyl orange) from contaminated water with remarkable efficiency (90-98%). The mechanistic analysis indicated the presence of pseudo-second-order reaction kinetics. The reusability of the hydrogel has been demonstrated by repeating the adsorption-desorption process over five cycles with identical results in the adsorption efficiency. (Graph Presented). © 2015 American Chemical Society.

Reusable Self-Healing Hydrogels Realized via in Situ Polymerization

We designed poly(aryl ether) dendron based transparent hydrogels containing glucose moiety, which undergoes in situ transition from nanofibers to spherical aggregates, upon pH variation. The process is reversible and the assembled structures have been characterized by DLS and SEM. More importantly, efficient dispersion of graphene oxide results in lower CGC (0.08 wt%) value and higher mechanical strength, compared to the native gel. © 2013 The Royal Society of Chemistry.

Chemical Communications

Glucose-cored poly(aryl ether) dendron based low molecular weight gels: PH controlled morphology and hybrid hydrogel formation

ACS Applied Materials & Interfaces

Polyisobutylene-Based pH-Responsive Self-Healing Polymeric Gels

Chemistry of Materials

Self-Healing Supramolecular Hydrogel Made of Polymers Bearing Cholic Acid and β-Cyclodextrin Pendants

Soft Matter

Self-healing polymer materials constructed by macrocycle-based host–guest interactions

Induction and Tunability of Self-Healing Property of Dendron Based Hydrogel Using Clay Nanocomposite

Journal	Data powered by TypesetJournal of Physical Chemistry B
Publisher	Data powered by TypesetAmerican Chemical Society
ISSN	15206106
Open Access	No