Department of Biotechnology, Indian Institute of Technology, Madras Madras, Tamil Nadu, India

Expertise

Biochemistry and Molecular Biology

Discrimination of membrane proteins based on structure and function, Prediction of membrane spanning segments in alpha-helical and beta-barrel membrane proteins, Recognition of protein folds.

Research Interests

• Discrimination of membrane proteins based on structure and function
• Prediction of membrane spanning segments in alpha-helical and beta-barrel membrane proteins
• Recognition of protein folds
• Prediction of secondary and tertiary structures in globular proteins
• Conformational stability of proteins and nucleic acids
• Identification of important residues for protein stability and function
• Extreme stability of thermophilic proteins

• Prediction of protein stablity upon amino acid substitutions
• Medium and Long Range Interactions in Gobular Proteins
• Development of novel parameters/methods for understanding/predicting protein folding rates
• Development of thermodynamic and functional databases for proteins and interactions
• Structural analysis of proteins and their interactions
• Elastic characters of DNA/RNA and importance to binding specificity
• Computer simulation of protein-DNA interactions
• Recognition mechanism for protein-protein, protein-nucleic acid, protein-carbohydrate and protein-ligand interactions

Personal Homepage: http://www.iitm.ac.in/bioinfo/Gromiha/index.html