The research toward finding optimal material layout (topology optimization) with design-dependent loads has been going on for more than two decades now. In almost all these research works, the material model is assumed to be isotropic. This work presents the method and demonstrates topology optimization with design-dependent loads for an orthotropic material model. Minimization of structural compliance is selected as the objective, with a constraint on the material used. The solid anisotropic material with penalization (SAMP) model relates elastic constants and element density. A simple boundary identification method is proposed in order to find the load curve. Once the load curve is obtained, loads are directly applied to the nodes of the boundary elements. Finally, numerical examples are presented to demonstrate the proposed approach. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.