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Therapeutic targets and computational approaches on drug development for covid-19Published in Bentham Science Publishers
2020
PMID: 32648845
Volume: 20
Issue: 24
Pages: 2210 - 2220
World Health Organization declared coronavirus disease (COVID-19) caused by SARS coronavirus-2 (SARS-CoV-2) as pandemic. Its outbreak started in China in Dec 2019 and rapidly spread all over the world. SARS-CoV-2 has infected more than 800,000 people and caused about 35,000 deaths so far, moreover, no approved drugs are available to treat COVID-19. Several investigations have been carried out to identify potent drugs for COVID-19 based on drug repurposing, potential novel compounds from ligand libraries, natural products, short peptides, and RNAseq analysis. This review is focused on three different aspects; (i) targets for drug design (ii) computational methods to identify lead compounds and (iii) drugs for COVID-19. It also covers the latest literature on various hit molecules proposed by computational methods and experimental techniques. © 2020 Bentham Science Publishers.
Topics: Drug development (54)%54% related to the paper and Drug repositioning (52)%52% related to the paper
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About the journal
| Journal | Current Topics in Medicinal Chemistry |
|---|---|
| Publisher | Bentham Science Publishers |
| ISSN | 15680266 |
| Open Access | No |
Authors (3)
M. Michael Gromiha- Investigating mutation-specific biological activities of small molecules using quantitative structure-activity relationship for epidermal growth factor receptor in cancer
- Real value prediction of protein folding rate change upon point mutation
- Organocatalytic Enantioselective Assembly of Spirooxindole-naphthopyrans through Tandem Friedel-Crafts Type/Hemiketalization
- Sequence analysis and discrimination of amyloid and non-amyloid peptides
V R Muraleedharan- Anti-malarial policy in the madras presidency: An overview of the early decades of the twentieth century
- Regulating India's health services: To what end? What future?
- Quinine (Cinchona) and the incurable malaria: India c. 1900-1930s
- Economic and societal impact of a systems-of-care approach for stemi management in low and middle-income countries: Insights from the tn stemi program
R. Velmurugan- Numerical and experimental study of multimode failure phenomena in GFRP laminates of different lay-ups
- Influence of fibre orientation and thickness on the response of CFRP composites subjected to high velocity impact loading
- Reliability analysis of tensile strengths using Weibull distribution in glass/epoxy and carbon/epoxy composites
- Study of rate dependent behavior of glass/epoxy composites with nanofillers using non-contact strain measurement
