The use of computational chemistry techniques via molecular modeling software provides additional support to the hair surface model by Negri et al. (1) and refines the thickness of the 18-methyl eicosanoic acid (18-MEA) lipid layer attached by thioester linkages to an ultra-high-sulfur protein (UHSP) at 1.08 ± 0.2 nm. This value compares favorably to the thickness of that same layer from X-ray photoelectron spectroscopy (XPS) measurements by Ward et al. (2) at 1.00 ± 0.5 nm on Soxhlet-extracted wool. The model clarifies that the results of Ward et al. via XPS are not an artifact of high vacuum (3), but due to relaxation of the 18-MEA structure onto the wool protein backbone as suggested by Zahn et al. (4). In this molecular model, 18-MEA is attached to beta sheets of an UHSP via thioester linkages as suggested by Negri et al. in their 1993 study (15) and by earlier work by Evans et al. (5). The beta sheets of this model provide an intersheet spacing of 0.7 nm and a beta sheet density of 1.42 g/cm3 compared with Allworden membrane fractions that varied from 1.39 to 1.54 g/cm3(6).