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The role of human phospholipid scramblases in apoptosis: An overview
Published in Elsevier B.V.
2017
PMID: 28844836
Volume: 1864
   
Issue: 12
Pages: 2261 - 2271
Abstract
Human phospholipid scramblases (hPLSCRs) are a family of four homologous single pass transmembrane proteins (hPLSCR1-4) initially identified as the proteins responsible for Ca2+ mediated bidirectional phospholipid translocation in plasma membrane. Though in-vitro assays had provided evidence, the role of hPLSCRs in phospholipid translocation is still debated. Recent reports revealed a new class of proteins, TMEM16 and Xkr8 to exhibit scramblase activity challenging the function of hPLSCRs. Apart from phospholipid scrambling, numerous reports have emphasized the multifunctional roles of hPLSCRs in key cellular processes including tumorigenesis, antiviral defense, protein and DNA interactions, transcriptional regulation and apoptosis. In this review, the role of hPLSCRs in mediating cell death through phosphatidylserine exposure, interaction with death receptors, cardiolipin exposure, heavy metal and radiation induced apoptosis and pathological apoptosis followed by their involvement in cancer cells are discussed. This review aims to connect the multifunctional characteristics of hPLSCRs to their decisive involvement in apoptotic pathways. © 2017
About the journal
JournalData powered by TypesetBiochimica et Biophysica Acta - Molecular Cell Research
PublisherData powered by TypesetElsevier B.V.
ISSN01674889
Open AccessYes
Concepts (37)
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    CARDIOLIPIN
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    DEATH RECEPTOR
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    Heavy metal
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    Phosphatidylserine
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    SCRAMBLASE
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    ANOCTAMIN
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    Apoptosis regulatory protein
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    Calcium
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    CARDIOLIPIN
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    DEATH RECEPTOR
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    Membrane protein
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    Phospholipid
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    PHOSPHOLIPID TRANSFER PROTEIN
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    PLSCR1 PROTEIN, HUMAN
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    XKR8 PROTEIN, HUMAN
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    Apoptosis
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    Cancer cell
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    Cell death
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    Human
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    Nonhuman
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    Priority journal
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    Radiation
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    Review
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    Transcription regulation
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    Genetics
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    Metabolism
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    Neoplasm
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    Pathology
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    ANOCTAMINS
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    Apoptosis regulatory proteins
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    CARDIOLIPINS
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    Humans
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    Membrane proteins
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    Neoplasms
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    PHOSPHOLIPID TRANSFER PROTEINS
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    Phospholipids
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    RECEPTORS, DEATH DOMAIN