An efficient and convenient synthesis of advanced (highly functionalized) tricyclic frame works present in the isofuranonaphthalenone, nodulones A-C and xestolactone A natural products has been achieved. The dehydro Diels-Alder reaction was employed as the key step for the construction of tricyclic systems. © 2016 Elsevier Ltd

Beeraiah Baire

Department Of Chemistry

Bhavani Shankar Chinta

Akshay Siraswar

naphthalene derivative

natural product

NODULONE A

NODULONE B

NODULONE C

unclassified drug

XESTOLACTONE A

article

Cycloaddition

Diels Alder reaction

drug structure

drug synthesis

priority journal

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

Tetrahedron

Rapid synthesis of the [5-5-6-6] tetracyclic system in the spirobionaphthalene natural product spiropreussione B was achieved. An intramolecular, thermal dehydrogenative Diels–Alder reaction was employed as the key step. Furthermore, this approach was extended to generate a library of structurally novel linear tetracyclic systems of spiropreussione B in a highly efficient manner. This report constitutes the first synthetic approach to the spiropreussione B natural product. © 2017 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim

European Journal of Organic Chemistry

First Synthesis of the [5-5-6-6] Tetracyclic Framework of Spiropreussione B

Françoise Colobert

ChemInform

ChemInform Abstract: Counting on Natural Products for Drug Design

Nature

The pentadehydro-Diels–Alder reaction

Journal of Natural Products

Natural Products as Sources of New Drugs from 1981 to 2014

Chemistry - A European Journal

Daldionin, an Unprecedented Binaphthyl Derivative, and Diverse Polyketide Congeners from a Fungal Orchid Endophyte

The dehydro Diels-Alder (DDA) reaction based approach to isofuranonaphthalenone, nodulones A-C and xestolactone A

Journal	Data powered by TypesetTetrahedron
Publisher	Data powered by TypesetElsevier Ltd
ISSN	00404020
Open Access	No