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Synthesis and anticancer activity of novel curcumin-quinolone hybrids
Saiharish A.V. Raghavan
Published in Elsevier Ltd
2015
PMID: 26174555
Volume: 25
   
Issue: 17
Pages: 3601 - 3605
Abstract
A number of new curcumin-quinolone hybrids were synthesised from differently substituted 3-formyl-2-quinolones and vanillin and their in vitro cytotoxicity was determined on a panel of representative cell lines (A549, MCF7, SKOV3 and H460) using MTT assay. The most potent compound 14, was analysed for its mode of action using various cell biology experiments. SKOV3 cells treated with compound 14 showed distorted cell morphology under phase contrast imaging and induction of apoptosis was confirmed by Annexin V/PE assay. Further experiments on generation of reactive oxygen species (ROS) and cell cycle analysis revealed that these hybrids induce apoptosis by ROS generation and arrest cell cycle progression in S and G2/M phase. © 2015 Elsevier Ltd.
About the journal
JournalData powered by TypesetBioorganic and Medicinal Chemistry Letters
PublisherData powered by TypesetElsevier Ltd
ISSN0960894X
Open AccessNo
Concepts (46)
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    3 FORMYL 2 QUINOLONE DERIVATIVE
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    Antineoplastic agent
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    Cisplatin
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    Curcumin
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    Quinolone derivative
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    Reactive oxygen metabolite
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    Unclassified drug
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    VANILLIN
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    A549 CELL LINE
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    Antineoplastic activity
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    Apoptosis
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    Article
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    Cancer cell line
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    Cell cycle progression
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    Cell structure
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    Cell viability
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    Controlled study
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    Cytology
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    Cytotoxicity
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    Drug mechanism
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    Drug potency
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    Drug structure
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    Drug synthesis
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    Flow cytometry
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    G2 phase cell cycle checkpoint
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    IC50
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    In vitro study
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    Mcf 7 cell line
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    Mtt assay
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    Oxidative stress
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    PHASE CONTRAST MICROSCOPY
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    S PHASE CELL CYCLE CHECKPOINT
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    Analogs and derivatives
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    Cell cycle
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    Chemistry
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    Drug effects
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    Human
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    Metabolism
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    Neoplasms
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    Synthesis
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    Tumor cell line
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    Antineoplastic agents
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    Cell line, tumor
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    Humans
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    Quinolones
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    Reactive oxygen species