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Protein aggregation: in silico algorithms and applications
, , Prabakaran R., Rawat P., Thangakani A.M.
Published in Springer Science and Business Media Deutschland GmbH
Volume: 13
Issue: 1
Pages: 71 - 89
Protein aggregation is a topic of immense interest to the scientific community due to its role in several neurodegenerative diseases/disorders and industrial importance. Several in silico techniques, tools, and algorithms have been developed to predict aggregation in proteins and understand the aggregation mechanisms. This review attempts to provide an essence of the vast developments in in silico approaches, resources available, and future perspectives. It reviews aggregation-related databases, mechanistic models (aggregation-prone region and aggregation propensity prediction), kinetic models (aggregation rate prediction), and molecular dynamics studies related to aggregation. With a multitude of prediction models related to aggregation already available to the scientific community, the field of protein aggregation is rapidly maturing to tackle new applications. © 2021, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.
About the journal
JournalData powered by TypesetBiophysical Reviews
PublisherData powered by TypesetSpringer Science and Business Media Deutschland GmbH
Open AccessNo