Synthesis of β-keto esters by condensing various aldehydes with ethyl diazoacetate is achieved by using molybdenum(VI) dichloride dioxide. Aromatic, aliphatic, and heterocyclic aldehydes are successfully condensed with ethyl diazoacetate to obtain corresponding β-keto esters in high yields at room temperature.

Dillip Kumar Chand

Department Of Chemistry

Kandasamy Jeyakumar

Aldehydes

Aromatic compounds

Esterification

Esters

Molybdenum

Vegetation

C-H INSERTION

CATALYZED SYNTHESIS

ETHYL DIAZOACETATE (EDA)

HETEROCYCLIC ALDEHYDES

Keto esters

Room-temperature (RT)

SYNTHESIS (OF CHIRAL IONIC LIQUIDS)

Organic compounds

2 NAPHTHALDEHYDE

aldehyde derivative

benzaldehyde

DIAZOACETIC ACID ETHYL ESTER

ester derivative

Furfural

MOLYBDENUM DICHLORIDE DIOXIDE

PICOLINALDEHYDE

article

catalysis

catalyst

chemical analysis

chemical reaction kinetics

Microwave irradiation

microwave radiation

Room temperature

synthesis

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

Synthesis

Selective oxidation of sulfides to sulfoxides and sulfones is achieved by H2O2 using MoO2Cl2 as the catalyst. Various substituted sulfides having functional groups such as methyl, methoxy, bromo, nitro, alkene, alkyne, alcohol, ester, aldehyde and remarkably an oxime are successfully and selectively oxidized without affecting the sensitive functionalities. © 2006 Elsevier Ltd. All rights reserved.

Tetrahedron Letters

Selective oxidation of sulfides to sulfoxides and sulfones at room temperature using H2O2 and a Mo(VI) salt as catalyst

Selective and controlled aerobic oxidation of activated benzyl alcohols to the corresponding aldehydes is achieved in refluxing CH3CN using catalytic amounts of MoO2Cl2(L)2 where L is DMSO, DMF or THF. The catalysis reactions are possible under open air in the absence of any other external co-oxidants. However, bubbling of oxygen to the reaction mixture is useful in making the catalysis reaction sustained. Both activated and deactivated varieties of α-substituted benzyl alcohols (secondary alcohols) give ketones in the same reaction conditions. The inexpensive catalyst is selective towards activated primary benzyl alcohols and also, being mild, stops the oxidation at the aldehyde stage, making it synthetically useful. Copyright © 2006 John Wiley &amp; Sons, Ltd.

Applied Organometallic Chemistry

Aerobic oxidation of benzyl alcohols by MoVI compounds

Purification of Laboratory Chemicals

Purification of Organic Chemicals

ChemInform

ChemInform Abstract: Activated Alumina-Promoted Reaction of Aldehydes with Ethyl Diazoacetate: A Simple Route to β-Oxo Esters.

Synlett

Deoxygenation ofN-Oxides with Triphenylphosphine, Catalyzed by ­Dichlorodioxomolybdenum(VI)

Molybdenum(VI) dichloride dioxide catalyzed synthesis of β-keto esters by C-H insertion of ethyl diazoacetate into aldehydes

Journal	Synthesis
ISSN	00397881
Open Access	No