A high yield one-pot method for the synthesis of amides from alcohols is described. The aldehyde was generated in situ using iodine-TEMPO as oxidizing agent followed by intermediate oxime formation through reaction with NH 2OH•HCl and finally rearrangement of oxime catalyzed by FeCl 3. © 2012 Elsevier B.V. All rights reserved.

Rima Das

Debashis Chakraborty

FECL 3

High yield

In-situ

One pot

One-pot method

Oxidizing agents

OXIME FORMATION

SYNTHESIS OF AMIDE

alcohols

Aldehydes

CATALYSTS

Iodine

oxidation

Reaction intermediates

Amides

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

Catalysis Communications

A direct synthetic route for the transformation of aldehydes into primary amides in the presence of catalytic amounts of FeCl3 in water is described. A direct synthetic route for the transformation of aldehydes into primary amides in the presence of catalytic amounts of FeCl3 in water is described. Copyright © 2011 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.

European Journal of Organic Chemistry

FeIII-catalyzed synthesis of primary amides from aldehydes

Advanced Synthesis & Catalysis

10.1002/adsc.v352.18

One-Pot Synthesis of Symmetrical 1,3-Diarylureas or Substituted Benzamides Directly from Benzylic Primary Alcohols and Effective Oxidation of Secondary Alcohols to Ketones Using Phenyliodine Diacetate in Combination with Sodium Azide

Tetrahedron Letters

Metal-free one-pot oxidative conversion of benzylic alcohols and benzylic halides into aromatic amides with molecular iodine in aq ammonia, and hydrogen peroxide

Chemistry - A European Journal

The “Borrowing Hydrogen Strategy” by Supported Ruthenium Hydroxide Catalysts: Synthetic Scope of Symmetrically and Unsymmetrically Substituted Amines

I 2-TEMPO as an efficient oxidizing agent for the one-pot conversion of alcohol to amide using FeCl 3 as the catalyst

Journal	Catalysis Communications
ISSN	15667367
Open Access	No