Recently, the application of the microbial fuel cell (MFC)-based biosensor for rapid and real-time monitoring wastewater quality is very innovative due to its simple compact design, disposability, and cost-effectiveness. This review represents recent advances in this emerging technology for the management of wastewater quality, where the emphasis is on biochemical oxygen demand, toxicity, and other environmental applications. In addition, the main challenges of this technology are discussed, followed by proposing possible solutions to those challenges based on the existing knowledge of detection principles and signal processing. Potential future research of MFC-based biosensor has been demonstrated in this review. © 2019 Elsevier B.V.