Header menu link for other important links
X
Investigation of the enantioselective synthesis of 2,3- Dihydroquinazolinones Using Sc(III)- Inda -pybox
Muthuraj Prakash, Samydurai Jayakumar,
Published in
2013
Volume: 45
   
Issue: 16
Pages: 2265 - 2272
Abstract
Derivatives of 2,3-dihydroquinazolinones (2,3-DHQZs) are prized for their prevalent pharmaceutical applications. Although there are potential applications, methods available for the enantioselective synthesis of these valuable compounds are scarce, since the chiral aminal center is prone to racemization. We have overcome the difficulties in the catalytic enantioselective synthesis of 2,3-DHQZs using Sc(III)-inda-pybox as a catalyst, in a process with a broad substrate scope. © Georg Thieme Verlag Stuttgart. New York.
About the journal
JournalSynthesis (Germany)
ISSN00397881
Open AccessYes
Concepts (26)
  •  related image
    Asymmetric catalysis
  •  related image
    DIHYDROQUINAZOLINONES
  •  related image
    Enantioselective synthesis
  •  related image
    Pharmaceutical applications
  •  related image
    PYBOX
  •  related image
    Triflates
  •  related image
    Chelation
  •  related image
    Scandium compounds
  •  related image
    Enantioselectivity
  •  related image
    2 (1,3 BENZODIOXOL 5 YL) 3 PHENYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE
  •  related image
    2 ALKYL 2,3 DIHYDROQUINAZOLINONE DERIVATIVE
  •  related image
    2 ARYL 2,3 DIHYDROQUINAZOLINONE DERIVATIVE
  •  related image
    2 ETHYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE
  •  related image
    2 PENTYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE
  •  related image
    2,3 DIARYL 2,3 DIHYDROQUINAZOLINONE DERIVATIVE
  •  related image
    2,3 DIHYDROQUINAZOLINONE DERIVATIVE
  •  related image
    Quinazolinone derivative
  •  related image
    Scandium
  •  related image
    Unclassified drug
  •  related image
    Analytical parameters
  •  related image
    Article
  •  related image
    Catalysis
  •  related image
    Cyclization
  •  related image
    Drug structure
  •  related image
    Drug synthesis
  •  related image
    Reaction optimization