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Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19
, , Muralidharan Nisha, Sakthivel R.
Published in Informa UK Limited
2020
PMID: 32248766
Volume: 39
   
Issue: 7
Pages: 2673 - 2678
Abstract

A novel coronavirus, formally named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused coronavirus disease 2019 (COVID-19) worldwide, and it is the latest pandemic in the series of other infectious diseases including avian flu, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). According to the World Health Organization, SARS-CoV-2 has caused an initial outbreak in Wuhan, China in the end of December 2019 and affected 82,000 people approximately and caused deaths of around 3,000 people till date in that country alone. Rapidly, it has become a global pandemic and spread to other countries such as Republic of Korea, Thailand, Iran, Italy, United States of America, India, etc., affecting more than 800,000 people with around 40,000 deaths worldwide (World Health Organization data as reported by national authorities by 10 AM CET 01 April 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200401-sitrep-72-covid-19.pdf?sfvrsn=3dd8971b_2). Hence, it is the utmost public health emergency at present.

About the journal
JournalJournal of Biomolecular Structure and Dynamics
PublisherInforma UK Limited
ISSN07391102
Open AccessNo