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A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors
, Ramesh Mukkamala
Published in American Chemical Society
2015
PMID: 25534018
Volume: 17
   
Issue: 2
Pages: 194 - 197
Abstract
A common building block for the synthesis of amorfrutin and cajaninstilbene acid derivatives has been developed. The library of synthesized compounds has enabled identification of new nontoxic ligands of peroxisome proliferator-activated receptors (PPAR) and potential inhibitors of the transcriptional corepressor protein NCoR. The biological data holds promise in identification of new potential leads for the antidiabetic drug discovery process. © 2014 American Chemical Society.
About the journal
JournalData powered by TypesetOrganic Letters
PublisherData powered by TypesetAmerican Chemical Society
ISSN15237060
Open AccessYes
Concepts (13)
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    3-HYDROXY-4-PRENYL-5-METHOXYSTILBENE-2-CARBOXYLIC ACID
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    AMORFRUTIN A
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    HYPOGLYCEMIC AGENTS
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    Ligands
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    PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
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    Salicylates
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    Stilbenes
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    Chemical synthesis
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    Chemistry
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    Metabolism
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    Molecular structure
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    HYPOGLYCEMIC AGENTS
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    PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS