A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting l-(+)-tartaric acid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ- unsaturated ketoacids and urea under environmentally benign and simple reaction conditions. © The Royal Society of Chemistry 2013.

Sundarababu Baskaran

Department Of Chemistry

Sangram Gore

APLYSINOPSIN

CYTOTOXIC AGENT

DANTROLENE

GLPG 0492

HYDANTOIN DERIVATIVE

OXOACID

PHENYTOIN

SELECTIVE ANDROGEN RECEPTOR MODULATOR

unclassified drug

article

drug structure

drug synthesis

Fulltext

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

Chemical Communications

Functionalized indoles are synthezised under mild conditions in a tartaric acid-dimethylurea melt. The melt serves as the solvent and as the catalyst. Under these reaction conditions, sensitive functional groups such as N-Boc, N-Cbz, or azides are stable, and indolenines are obtained regioselectively in excellent yields. The practical use of the method is demonstrated in the synthesis of the hormone melatonin. © 2012 American Chemical Society.

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Journal	Data powered by TypesetChemical Communications
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	13597345
Open Access	Yes