Peptide segments with centrally placed sulfamide groups showed a remarkable tendency to adopt a turn conformation and exhibited supramolecular topologies like 'helical stacks' and 'hairpin sheets' through a highly coordinated array of strong and weak hydrogen bonds. This journal is © the Partner Organisations 2014.

Kannoth Manheri Muraleedharan

Department Of Chemistry

Venkatachalam Ramkumar

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

CrystEngComm

A design approach that incorporates structural requirements for the formation of a 1D assembly, fibril stability, and fibril–fibril interactions for gelation was attempted by using amino acid-based sulfamides with the general structure Aa-NH-SO2-NH-Aa (Aa=amino acid). A preference for 1D assembly alone was not a sufficient condition for gelation, which became evident from studies involving sulfamide esters 1–5. Reducing the crystallization tendency without hindering unidirectional growth was executed through diacids of the sulfamide precursors with various amines that form an envelope around the sulfamide core through salt bridges. This strategy was fruitful, and gels of a wide variety of solvents could be formed by varying the acid and amine components. The use of dodecylamine or benzylamine, which could stabilize the molecular layers through alkylchain segregation or π–π interactions improved the gelation tendency, whereas the nature of the amino acid side chain, especially the rotational freedom and hydrophobicity, had a direct role in dictating the solvent preference. Crystallographic studies of these two-component systems gave molecular- level insight into the assembly and showed the importance of anisotropy in the distribution of secondary interactions in gelation. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemistry - A European Journal

Sulfamide-lattice restructuring to form dimensionally controlled molecular arrays and gel-forming systems

Supramolecular single-stranded calix[4]arene helices—towards a crystal engineering approach of homochiral assemblies

Proceedings of the National Academy of Sciences

Evaluating  -turn mimics as  -sheet folding nucleators

Expert Opinion on Therapeutic Targets

10.1517/ett.2008.12.issue-12

Small

Construction of Helical Nanofibers from Self-Assembling Pseudopeptide Building Blocks: Modulating the Handedness and Breaking the Helicity

Organic Letters

Diastereoselective Pictet−Spengler Approach for the Synthesis of Pyrrolo[3,2-e][1,4]diazepin-2-one Peptide Turn Mimics

Peptide turns through just 'one atom'! A sulfamide group nucleates folding and stabilizes new supramolecular topologies in short peptides

Journal	Data powered by TypesetCrystEngComm
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	14668033
Open Access	No