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Naturally occurring variants of the dysglycemic peptide pancreastatin: Differential potencies for multiple cellular functions and structure-function correlationOpen AccessPublished in
2014
PMID: 24338022
Volume: 289
Issue: 7
Pages: 4455 - 4469
Background: Pancreastatin is a potent physiological regulator of plasma glucose/insulin. Results: We discovered two human variants of pancreastatin that are profoundly more potent than the wild-type peptide. Conclusion: Higher potencies of the variants correlate well with their enhanced propensity to adopt longer helical structures than the wild-type peptide. Significance: These findings provide new insights into the mechanism of human metabolic diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
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Content may be subject to copyright.This is a bronze open access articleThis is a bronze open access article
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About the journal
| Journal | Journal of Biological Chemistry |
|---|---|
| ISSN | 00219258 |
| Open Access | Yes |
Authors (3)
Amal Kanti Bera- Identification and Functional Characterization of Genetic Variants of the Catecholamine Release-Inhibitory Peptide Catestatin in an Indian Population
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- Cytotoxic helix-rich oligomer formation by melittin and pancreatic polypeptide
Sanjib Senapati- Structural plasticity of cholesteryl ester transfer protein assists the lipid transfer activity
- Identification and Functional Characterization of Genetic Variants of the Catecholamine Release-Inhibitory Peptide Catestatin in an Indian Population
- Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimer's Disease
- How cholesteryl ester transfer protein can also be a potential triglyceride transporter
Nitish R. Mahapatra- Identification and Functional Characterization of Genetic Variants of the Catecholamine Release-Inhibitory Peptide Catestatin in an Indian Population
- Regulation of Monoamine Oxidase B Gene Expression: Key Roles for Transcription Factors Sp1, Egr1 and CREB, and microRNAs miR-300 and miR-1224
- Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension
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Concepts (27)
Genetic polymorphism- Glucose metabolism
- Glucose uptake
- Human genetic variation
- Metabolic diseases
- Metabolic disorder
- Molecular modeling
- Nitric oxide
- Pancreastatin
- Peptide hormones
- 3t3-l1 cells
- Adult
- Amino acid substitution
- Animals
- Blood glucose
- Circular dichroism
- Female
- Genetic variation
- Hep g2 cells
- Humans
- Insulin
- Male
- Mice
- Mutation, missense
- Pancreatic hormones
- Protein structure, tertiary
- Structure-activity relationship
