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Nanofibers coated on acellular tissue-engineered bovine pericardium supports differentiation of mesenchymal stem cells into endothelial cells for tissue engineering
Dillip Kumar Bishi, Soma Guhathakurta,
Published in Future Medicine Ltd.
2014
PMID: 24827842
Volume: 9
   
Issue: 5
Pages: 623 - 634
Abstract

Aim: This study aimed to develop biodegradable, polymer-based nanofibers coated on acellular tissue-engineered bovine pericardium (ATEBP) for cell interfaces, enabling more exquisite functionality, such as mesenchymal stem cell (MSC) adhesion, proliferation and differentiation into endothelial cells for tissue engineering. Materials & methods: ATEBP coated with nanofibers of poly(L-lactic acid)-co-poly(ε-caprolactone) (PLACL) and a blend of PLACL and gelatin were analyzed for human bone marrow-derived MSC adhesion, proliferation and differentiation into endothelial cells. Results: The cell culture-based approach showed an increase in human bone marrow-derived MSC adhesion, proliferation and differentiation into endothelial cells on ATEBP coated with PLACL/gelatin nanofibers compared with ATEBP and PLACL nanofibers coated on ATEBP. Conclusion: ATEBP coated with PLACL/gelatin nanofibrous scaffolds, along with human bone marrow-derived MSCs differentiated into endothelial cells, might improve the scaffolds' functionality for tissue engineering. Original submitted 5 July 2012; Revised submitted 24 January 201. © 2014 Future Medicine Ltd.

About the journal
JournalNanomedicine
PublisherFuture Medicine Ltd.
ISSN17435889
Open AccessNo
Concepts (59)
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    Gelatin
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    Nanofiber
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    Polycaprolactone
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    Polylactic acid
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    POLYLACTIC ACID CO POLYCAPROLACTONE
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    Polymer
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    Unclassified drug
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    Biomaterial
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    Adult
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    Animal tissue
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    Article
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    Cell adhesion
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    Cell differentiation
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    Cell proliferation
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    Controlled study
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    Endothelium cell
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    HEMATOPOIETIC STEM CELL
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    Histology
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    Human
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    Human cell
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    Human cell culture
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    IMMUNOCYTOCHEMISTRY
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    Infrared spectroscopy
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    Mesenchymal stem cell
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    Nonhuman
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    PERICARDIUM
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    Priority journal
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    TISSUE ENGINEERED BOVINE PERICARDIUM
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    Tissue engineering
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    Animal
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    Bovinae
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    Cell free system
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    Cell line
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    Chemistry
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    Cytology
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    Device failure analysis
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    Devices
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    Extracellular matrix
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    Materials testing
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    Mesenchymal stroma cell
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    Particle size
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    PERICARDIUM
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    Physiology
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    Prosthesis
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    Synthesis
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    Tissue scaffold
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    Ultrastructure
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    Animals
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    Cattle
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    Cell-free system
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    Coated materials, biocompatible
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    Endothelial cells
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    Equipment failure analysis
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    Humans
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    Mesenchymal stromal cells
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    Nanofibers
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    PERICARDIUM
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    Prosthesis design
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    Tissue scaffolds