The dataset presented in the article includes the timestamp of key press and key release data of individual participants during a novel finger thumb opposition typing task. The novel task involves touching different segments (phalanges) of fingers with the thumb to type a specific symbol on the computer screen. This task involves learning of set of sequences by typing or touching them using the finger thumb opposition movements is termed as motor sequence learning task or paradigm. The symbol set comprised of nine most frequently used symbols in English. From the nine symbols, a set of 281 meaningful five lettered words (sequences) were formed. These sequences were presented to the participants in a game-like interface. Once a specific symbol was pressed and released the time stamp was registered in the computer as key (symbol) press and key release information. The dataset consists of three columns, first column shows the pressed key, second column the registered timestamp and final column shows the symbol activity with respect to the first symbol in terms of milliseconds. Key press information is followed by key release information. This is represented in the dataset as “LCONTROL” in the first column of the data. Changes of this key press and key release information over the course of practice can be used to understand change in performance of this novel tying task.