This paper presents the experimental and numerical investigations on the cold-formed steel beam-column members under bi-axial loading. In this study, the lipped channel cross-section of members are considered for the investigation on the cross-sectional and global buckling effects on the strength of the member. Experiments are conducted by applying an eccentric compression to create axial load and a moment gradient. Carefully designed experiments are carried out so that the member will be subjected to uniform and non-uniform moments throughout the member. The influence of varying moment on the various buckling behavior is examined. The use of moment correction factor (Cb) in the case of FTB and distortional buckling is discussed. The study presents the influence of moment amplification factor (Cm) on the strength prediction. A study is also carried out using ABAQUS, which is then validated with the experimental results. The numerical model is extended to study the behavior of a spectrum of axial and bending combinations. The results from the experiment and numerical model are compared with the code specification AISI S100-16 for DSM design both for the linear interaction (LI) framework and the non-linear interaction (NLI) framework. The results show that the LI framework predicts strength conservatively by 30 to 90% for biaxial bending. The details of the study is presented in this paper. © 2020 by the Structural Stability Research Council. All Rights Reserved.