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Functional interaction of PkcA and PldB regulate aggregation and development in Dictyostelium discoideum
Published in Elsevier Inc.
2017
PMID: 28257811
Volume: 34
   
Pages: 47 - 54
Abstract
Multicellular development in Dictyostelium discoideum involves tightly regulated signaling events controlling the entry into development, initiation of aggregation and chemotaxis, and cellular differentiation. Here we show that PkcA, a Dictyostelium discoideum Protein Kinase C-orthologue, is involved in quorum sensing and the initiation of development, as well as cAMP sensing during chemotaxis. Additionally, by epistasis analysis we provide evidence that PkcA and PldB (a Phospholipase D-orthologue) functionally interact to regulate aggregation, differentiation, and cell-cell adhesion during development. Finally, we show that PkcA acts as a positive regulator of intracellular PLD-activity during development. Taken together, our results suggest that PkcA act through PldB, by regulating PLD-activity, in order to control events during development. © 2017 Elsevier Inc.
About the journal
JournalData powered by TypesetCellular Signalling
PublisherData powered by TypesetElsevier Inc.
ISSN08986568
Open AccessYes
Concepts (39)
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    Cyclic amp
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    PHOSPHOLIPASE D
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    PKCA PROTEIN
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    PLDB PROTEIN
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    Protein kinase c
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    Unclassified drug
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    Butanol
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    CELL ADHESION MOLECULE
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    CELL COHESION MOLECULE, DICTYOSTELIUM
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    PHOSPHATIDIC ACID
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    PHOSPHOLIPASE D
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    PHOSPHOLIPASE D1
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    PROTEIN KINASE C ALPHA
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    Protozoal protein
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    Article
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    Cell adhesion
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    Cell aggregation
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    Cell differentiation
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    Chemotaxis
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    Controlled study
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    Development
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    DICTYOSTELIUM DISCOIDEUM
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    Enzyme activity
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    Nonhuman
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    Protein protein interaction
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    Quorum sensing
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    Cell polarity
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    Dictyostelium
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    Drug effects
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    Growth, development and aging
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    Metabolism
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    Physiology
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    Signal transduction
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    Butanols
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    CELL ADHESION MOLECULES
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    PHOSPHATIDIC ACIDS
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    PHOSPHOLIPASE D
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    PROTEIN KINASE C-ALPHA
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    Protozoan proteins