ACS Sustainable Chemistry & Engineering (ACS SCE) was launched in January 2013, with a scope that included green chemistry, green engineering, and the grand challenges for sustainability in the chemical enterprise. As Editors, we have been honored by the response of the research community to the journal. Submissions and published content have grown by an order of magnitude since our launch, and as our fourth year came to a close, we were approaching 800 published articles per year. These publications are being widely cited, and the journal’s impact factor, which currently stands at 5.27, is on an upward trajectory. Given the number and high quality of submissions that ACS SCE is attracting, we chose this editorial venue at the start of our fifth year to comment on the scope and future directions of ACS SCE, providing clarifications based on our collective editorial experience.