Air bubbles are known to form at the liquid/solid interface of hydrophobic materials upon immersion in a liquid (Holmberg, M.; Kdühle, A.; Garnæs, J.; Mørch, K. A.; Boisen, A. Langmuir 2003, 19, 10510-10513). In the case of gravimetric sensors, air bubbles that randomly form at the liquid-solid interface result in poor sensor-to-sensor reproducibility. Herein a superhydrophilic ZnO nanorod film is applied to the originally hydrophobic surface of a resonance-based magnetoelastic sensor. The superhydrophilic coating results in the liquid completely spreading across the surface, removing unwanted air bubbles from the liquid/sensor interface. The resonance amplitude of uncoated (bare) and ZnO-modified sensors are measured in air and then when immersed in saline solution, ethylene glycol, or bovine blood. In comparison to the bare, hydrophobic sensors, we find that the standard deviation of the resonance amplitudes of the liquid-immersed ZnO-nanorod-modified sensors decreases substantially, ranging from a 27% decrease for bovine blood to a 67% decrease for saline. The strategy of using a superhydrophilic coating can be applied to other systems having similar interfacial problems. © 2008 American Chemical Society.