Header menu link for other important links
X
Effect of calcification on plaque stresses and vulnerability: A finite element study
Published in
2013
Volume: 20
   
Issue: 4
Pages: 309 - 315
Abstract
The factors responsible for atherosclerotic plaque rupture, the initiating event in the majority of acute coronary syndromes, have received a lot of attention in recent times. However, the effect of calcification on plaque vulnerability is still a matter of considerable debate. In order to clarify the effect of calcification on plaque stresses and vulnerability, parametric "what if" studies were conducted on a histology specimen of a coronary endarterectomy plaque using finite element analysis and the biomechanical stresses calculated. It was found that the maximum principle stresses may decrease, increase, or remain unchanged depending on the location of calcification within a plaque and the lumen shape. The effect of calcification on plaque stresses in a lipid-rich plaque is a consequence of a complex interplay of a number of factors including vessel geometry, lipid distribution, and patterns and site of calcification. © 2013 Copyright Taylor and Francis Group, LLC.
About the journal
JournalMechanics of Advanced Materials and Structures
ISSN15376494
Open AccessNo
Concepts (19)
  •  related image
    ACUTE CORONARY SYNDROMES
  •  related image
    Atherosclerosis
  •  related image
    ATHEROSCLEROTIC PLAQUE RUPTURES
  •  related image
    BIOMECHANICAL STRESS
  •  related image
    Finite-element study
  •  related image
    INITIATING EVENTS
  •  related image
    LIPID DISTRIBUTIONS
  •  related image
    Mechanical stress
  •  related image
    NUMBER OF FACTORS
  •  related image
    PRINCIPLE STRESS
  •  related image
    VESSEL GEOMETRY
  •  related image
    VULNERABLE PLAQUES
  •  related image
    Biomechanics
  •  related image
    Biomineralization
  •  related image
    Bone
  •  related image
    CALCIFICATION (BIOCHEMISTRY)
  •  related image
    Finite element method
  •  related image
    Thermoelectricity
  •  related image
    Stresses