Ductile failure by void growth in an elasto-plastic material subjected to non-proportional loading, involving step changes in the stress triaxiality or the Lode parameter, is investigated using periodic unit cell model simulations. The equivalent strains to failure by the onset of void coalescence, defined as the localization of plasticity along a band of voids at the micro-scale, are determined as a function of the loading path parameters. The observed trends for the ductility under non-proportional loading are found to be inconsistent with the predictions of a continuum damage mechanics model based on the attainment of a constant critical damage variable, even if the model has been calibrated to predict accurate results for the ductility under proportional loading. It is shown that a recently developed failure criterion based on the onset of plastic instability in a porous material, coupled with a micromechanics-based void growth law, predicts the loading path dependence of failure under non-proportional loading, in better agreement with the cell model simulation results than the continuum damage model. In particular, the triaxiality dependence of the ductility is found to be primarily due to the hydrostatic stress dependence of void growth, while the Lode dependence is primarily due to the instability-based failure criterion with a relatively minor effect of the Lode parameter on void growth. Implications of these findings on the current modeling approaches to ductile failure under shear dominated loading are discussed. © 2022 Elsevier Ltd