Percutaneous Left Ventricular Assist Device is used for short (1-2 weeks) of cardiac support and have strenuous design methodology as compared to conventional Left Ventricular Assist Device (LVAD). The aim of this study is (i) to design a micro-axial blood pump (ii) valídate the design using Computational Fluid Dynamics (CFD) and Systemic Mock Circulation Loop (SMCL), and (iii) flow visualization using Particle Image Velocimetry (PIV). The diameter of the impeller is 7.6 mm and length is 15 mm. One of the most important aspect of the design was the elimination of the bearing. The optimum parameters ascertained includes a wrap angle of 2500, blade thickness of 0.5 mm and shroud clearance of 0.25 mm. The straightener and diffusor were eliminated to reduce the net surface area exposed to blood. The pump characteristics were obtained using a Systemic Mock Circulation Loop (SMCL), developed in-house. The dynamic response was recorded by varying arterial compliance from 0.5 mL/mm Hg to 2 mL/mm Hg in SMCL. The design showed a consistent pump characteristics over a range of arterial compliance and an optimum flow rate of 2.5L/min at 60mm Hg, whereas the maximum flow rate of 2.8L/min at 80 mm Hg. The flow characteristics obtained using PIV were in good agreement with the CFD results. Copyright © 2020 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved