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Curcumin augments therapeutic efficacy of TRAIL-based immunotoxins in leukemia
, Surapally Sridevi,
Published in Springer Science and Business Media LLC
Volume: 72
Issue: 4
Pages: 1032 - 1046

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) has been perceived as a promising anti-cancer agent because of its unique ability to kill cancer cells while sparing normal cells. However, translation of TRAIL to clinical studies was less successful as a large number of cancer cells acquire resistance to TRAIL-based monotherapies. An ideal strategy to overcome TRAIL resistance is to combine it with potential sensitizing agents.

About the journal
PublisherData powered by TypesetSpringer Science and Business Media LLC
Open AccessNo