This study investigates the mechanistic approach to evaluate total stored energy consisting of damage energy (due to voids and microcracks) and deformation energy (due to dislocations). Thermal data obtained by online IRT technique have been employed for this evaluation. The deformation energy is estimated through EBSD analysis. Subsequently, the damage and deformation induced by creep and fatigue have been modeled as functions of applied stress and cumulative plastic strain, individually. By using the data of experimental creep stress and fatigue strain for each creep-fatigue cycle, the contributions of creep and fatigue damage energies have been estimated for creep-fatigue interaction. New fatigue and creep damage parameters have been proposed based on the damage mechanics concepts. Different regimes have been identified and explained with creep and fatigue damage evolution curves. The present approach has also been extended to characterize incremental creep-fatigue interactions. © 2017 Elsevier Ltd