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Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas
Geoffrey von Maltzahn, Ji-Ho Park, Amit Agrawal, Nanda Kishor Bandaru, Michael J. Sailor, , Sangeeta N. Bhatia
Published in American Association for Cancer Research (AACR)
2009
PMID: 19366797
Volume: 69
   
Issue: 9
Pages: 3892 - 3900
Abstract

Plasmonic nanomaterials have the opportunity to considerably improve the specificity of cancer ablation by i.v. homing to tumors and acting as antennas for accepting externally applied energy. Here, we describe an integrated approach to improved plasmonic therapy composed of multimodal nanomaterial optimization and computational irradiation protocol development. We synthesized polyethylene glycol (PEG)-protected gold nanorods (NR) that exhibit superior spectral bandwidth, photothermal heat generation per gram of gold, and circulation half-life in vivo (t 1/2, ∼17 hours) compared with the prototypical tunable plasmonic particles, gold nanoshells, as well as ∼2-fold higher X-ray absorption than a clinical iodine contrast agent. After intratumoral or i.v. administration, we fuse PEG-NR biodistribution data derived via noninvasive X-ray computed tomography or ex vivo spectrometry, respectively, with four-dimensional computational heat transport modeling to predict photothermal heating during irradiation. In computationally driven pilot therapeutic studies, we show that a single i.v. injection of PEG-NRs enabled destruction of all irradiated human xenograft tumors in mice. These studies highlight the potential of integrating computational therapy design with nanotherapeutic development for ultraselective tumor ablation. © 2009 American Association for Cancer Research.

About the journal
JournalData powered by TypesetCancer Research
PublisherData powered by TypesetAmerican Association for Cancer Research (AACR)
ISSN00085472
Impact Factor2.045
Open AccessYes
Citation StyleVancouver
Sherpa RoMEO Archiving PolicyYellow
Concepts (44)
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    Gold nanoparticle
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    Iodine
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    Macrogol
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    Animal experiment
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    Animal model
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    Article
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    Cancer chemotherapy
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    Cancer therapy
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    Comparative study
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    Computer assisted tomography
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    Controlled study
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    Drug distribution
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    Drug half life
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    EX VIVO STUDY
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    Human
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    Human cell
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    In vivo study
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    LIMB TUMOR
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    Mouse
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    Nonhuman
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    Phototherapy
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    PILOT STUDY
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    Priority journal
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    Radiation absorption
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    SINGLE DRUG DOSE
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    Spectrometry
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    TUMOR XENOGRAFT
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    X IRRADIATION
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    Animals
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    Breast neoplasms
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    Cell line, tumor
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    Gold
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    Humans
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    Hyperthermia, induced
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    Metal nanoparticles
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    Mice
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    Mice, nude
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    Nanotubes
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    Polyethylene glycols
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    Spectroscopy, near-infrared
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    Surface plasmon resonance
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    Tissue distribution
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    Tomography, x-ray computed
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    XENOGRAFT MODEL ANTITUMOR ASSAYS