An analytical model is presented for the configuration of Mach reflection (MR) due to the interaction of two-dimensional steady supersonic flow over asymmetric wedges. The present asymmetric MR model is an extension of an earlier model for the symmetric MR configuration. The overall Mach reflection (oMR) in the asymmetric wedge configuration is analysed as a combination of upper and lower half-domains of symmetric reflection configurations. Suitable assumptions are made to close the combined set of equations. The subsonic pocket downstream of the Mach stem is taken to be oriented along an average inclination, based on the streamline deflections by the Mach stem at the triple points. This assumption is found to give satisfactory results for all types of oMR configurations. The oMR configuration is predicted for all types of reflections such as direct Mach reflection (DiMR), stationary Mach reflection (StMR) and inverse Mach reflection (InMR). The reflection configuration and Mach stem shape given by the model for various sets of wedge angles, especially those giving rise to InMR, have been predicted and validated with the available numerical and experimental data. The von Neumann criterion for oMR is accurately predicted by this model. The asymmetric Mach stem profile is well captured. The variation of Mach stem height with wedge angle is also analysed and it is found that simplification of an asymmetric MR to a symmetric MR leads to over-prediction of the Mach stem height and hence the extent of the subsonic region. © 2019 Cambridge University Press.