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ADEQUATE CR: 13C connectivity mapping in indirect detection mode with composite refocusing
Published in John Wiley and Sons Ltd
2014
PMID: 24599710
Volume: 52
   
Issue: 5
Pages: 241 - 246
Abstract
We report a novel rare spin correlation experiment termed ADEQUATE with composite refocusing (CR), which is the 1H-detected version of 2D INADEQUATE CR. ADEQUATE CR begins with a polarization transfer from protons to the attached carbon, followed by 13C-13C double-quantum (DQ) preparation. Unlike the ADEQUATE class of experiments, 13C DQ coherence is converted after evolution to single-quantum single transitions (SQ-STs) by CR. 13C SQ-ST is then transferred back to the coupled protons by a coherence order selective reconversion. The present sequence produces partial transition selectivity in the 1H dimension as does 1H Indirect detected 13C Low-Abundance Single-transition correlation Spectroscopy (HICLASS), thereby mitigating the reduction in sensitivity enhancement because of the presence of homonuclear proton couplings. However, unlike HICLASS (which is an experiment that involves SQ-TS evolution), no homonuclear zero quantum mixing is required on the 13C channel in the present experiment. Experimental results are demonstrated on a variety of samples, establishing the efficiency of the proposed method. © 2014 John Wiley & Sons, Ltd.
About the journal
JournalData powered by TypesetMagnetic Resonance in Chemistry
PublisherData powered by TypesetJohn Wiley and Sons Ltd
ISSN07491581
Open AccessNo
Concepts (8)
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    Carbon
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    Proton
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    Nuclear magnetic resonance spectroscopy
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    Standard
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    Carbon isotopes
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    Magnetic resonance spectroscopy
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    Protons
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    REFERENCE STANDARDS