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Theoretical proof for the existence of cooperativity (experimental evidences have already been reported in our earlier work: Biochem. Biophys. Res. Commun., 293 (2002) 870) in the phenomenon of DNA renaturation has been obtained using a generalized birth-death master equation approach. Results have shown that no special searching mechanism (i.e. a facilitated mechanism) was necessary for complementary DNA strands to find their correct-contacts but searching by a 'random jump' method was enough to explain not only the observed cooperativity phenomenon but also the magnitude of correct-contact-forming rate constant. Impact of cooperativity phenomenon on length of primers and their specificity in polymerase chain reaction has also been discussed.
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Journal | Data powered by TypesetBiophysical Chemistry |
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Publisher | Data powered by TypesetElsevier |
ISSN | 0301-4622 |
Open Access | No |