Oxidation of propargylic alcohols to the corresponding aldehydes and ketones was achieved at room temperature using 2,2,6,6-tetramethylpiperidine-1- oxyl (TEMPO) and calcium hypochlorite (Ca(OCl)2). Propargylic diols yielded corresponding dialdehydes as the product. This system was found to be very efficient for both the electron donating and electron withdrawing groups such as methoxy and nitro substituted alcohols, respectively. This method does not require any additives and demonstrates the controlled, selective oxidation of propargylic alcohols affording up to 97% isolated yield. © The Royal Society of Chemistry 2013.

Anju Chadha

Department Of Biotechnology

Reddy S.R

Chadha A.

CALCIUM HYPOCHLORITE

DIALDEHYDES

Electron withdrawing group

Electron-donating

Isolated yield

Propargylic alcohols

Room temperature

Selective Oxidation

alcohols

calcium

Ketones

oxidation

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

RSC Advances

Novel N-chloro â-Lactam and benzisoxazole derivatives were successfully synthesized with excellent yields (92–96%) under simple and mild reaction conditions. The β-lactams as a class acquired importance since the discovery of penicillin which contains β-lactam unit as an essential structural feature of its molecule, this interest continued unabated because of the therapeutic importance of β-lactam antibiotics. In silico studies of the compounds with cancer drug target enzymes showed the inhibition of HDAC (Histone Deacetylase) and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) significantly. The compounds were then investigated for the inhibitory potential against the same enzymes in&nbsp;vitro. NF-κB inhibition was investigated by trans activation assay using HEK293/NF-κB-luc cells. Overall, the synthesized compounds induce the cancer cell toxicity by restraining the NF-κB transcription factor mediated by HDAC inhibition and thus the compounds act as dual inhibitors.

Chemico-Biological Interactions

HDAC and NF-κB mediated cytotoxicity induced by novel N-Chloro β-lactams and benzisoxazole derivatives

An efficient protocol for the synthesis of a variety of <a href="https://www.sciencedirect.com/topics/chemical-engineering/azobenzene">azobenzenes</a> and <a href="https://www.sciencedirect.com/topics/chemical-engineering/hydrazine">hydrazines</a> from aromatic <a href="https://www.sciencedirect.com/topics/chemical-engineering/amine">amines</a> under mild reaction conditions is developed using Cu(I) catalyst. The copper cataylst used in this study comprises of CuBr, DMAP and AIBN. The plausible proposed mechanism for this dehydrogenative homo coupling of aromatic amines is depicted.

Catalysis Communications

Cu(I) catalyzed dehydrogenative homo coupling of aromatic amines under simple and mild reaction conditions

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Synthetic Communications

Simplified procedure for TEMPO-catalyzed oxidation: Selective oxidation of alcohols, α-hydroxy esters, and amides using TEMPO and calcium hypochlorite

ChemInform

ChemInform Abstract: The Conversion of Aliphatic Primary Alcohols to the Corresponding Carboxylic Acids Using Calcium Hypochlorite.

The Journal of Organic Chemistry

Asymmetric Aerobic Oxidation of α-Hydroxy Acid Derivatives byC4-Symmetric, Vanadate-Centered, Tetrakisvanadyl(V) Clusters Derived fromN-Salicylidene-α-aminocarboxylates

Organic Letters

An Efficient Synthesis of Epoxydiynes and a Key Fragment of Neocarzinostatin Chromophore

Chemistry Letters

High Birefringent Bisdiynes and Hexatriynes Based on Double Elimination of β-Substituted Sulfones

A simple and efficient method for mild and selective oxidation of propargylic alcohols using TEMPO and calcium hypochlorite

Journal	RSC Advances
ISSN	20462069
Open Access	No