Department of Biotechnology, Indian Institute of Technology, Madras Chennai, Tamil Nadu, India
Biochemistry and Molecular Biology
Endothelial Dysfunction, atherosclerosis, endothelial progenitors.
The primary objective of my research team is to elucidate molecular and cellular mechanisms of normal and aberrant function of blood vessels under physiological and patho-physiological conditions respectively. The key areas we focus on are endothelial dysfunction, atherosclerosis and edema. In order to obtain a holistic picture on these issues we subscribe to the following approaches:
- High through put screening for identification of changes in gene expression from clinical samples.
- In vitro tissue culture experiments to identify signaling intermediates altered under pathological settings. For this we employ primary cultures of vascular smooth muscle cells (VSMCs), and human umbilical vein endothelial cells (HUVECs).
- Validation of in vitro data through in vivo animal experiments.
- Use of viral vector based gene delivery systems to rectify the faulty functioning of the signaling intermediates.