Commercial purity titanium (CP-Ti) was processed by equal channel angular pressing (ECAP) with a channel angle of 120 with the aim of studying the effect of microstructure on the wettability and bioactivity. Solid and tubular Ti rods of 6 mm diameter were ECAPed at room temperature. During ECAP of tubular specimens, hydroxyapatite was filled in the tube. Grains and sub-grains of size approximately 1 μm were observed using transmission electron microscopy in both solid and tubular samples. Vickers microhardness measurements and surface energy calculations showed good improvement for ECAPed samples. This can be attributed to the fine grain structure achieved after processing. However, tubular sample showed marginally higher hardness and wettability. In vitro bioactivity studies carried out using 1.5× SBF indicate enhanced bioactivity in ECAPed samples. Also, cell response using rat skeletal muscle (L6) cells was found to be promising for both solid and tubular ECAPed specimens. © 2013 Indian Institute of Metals.