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Versatile soluble oligomeric styrene supports for peptide synthesis
Venkataramana Erapalapati
Published in John Wiley and Sons Inc.
2015
Volume: 53
   
Issue: 21
Pages: 2501 - 2509
Abstract
Soluble oligomeric styrene supports are reported here with high loading capacities of 1.5-1.6 mmol/g similar to resins used in solid phase peptide synthesis. Oligoether and alkyl chains are incorporated into the scaffold to improve the support solubility and act as spacers between the attachment sites. Amino acids have been attached to the support in 59-85% yields and 0.87-1.3 mmol/g loading. The supports have been used to synthesize tri- to hexapeptides in 38-64% yields using only 2 equivalents of coupling reagents, which is much lower than the amount of reagents typically used in solid phase synthesis. A modular synthetic approach is used to obtain the supports so that any efficient styrene-based attachment site can be readily incorporated into our soluble support scaffold. © 2015 Wiley Periodicals, Inc.
About the journal
JournalData powered by TypesetJournal of Polymer Science, Part A: Polymer Chemistry
PublisherData powered by TypesetJohn Wiley and Sons Inc.
ISSN0887624X
Open AccessNo
Concepts (16)
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    Amino acids
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    Biosynthesis
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    Catalyst supports
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    Oligomers
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    Peptides
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    Scaffolds
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    Styrene
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    Coupling reagents
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    HIGH LOADINGS
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    OLIGOMERIC STYRENES
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    Peptide synthesis
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    Solid phase peptide synthesis
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    Solid phase synthesis
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    Soluble supports
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    Synthetic approach
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    Synthesis (chemical)