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Towards personalised medicine - The development of morphometric marker for alveolar deposition
Published in ILASS � Europe, Institute for Liquid Atomization and Spray Systems
Inter-subject variability in lung morphometry could influence the transport of any disease causing microorganism to the deep lung regions and the delivery of drug to such a targeted site. This study aims in establishing the relation between aerosol deposition and parameters determining the lung morphometry. The human respiratory system is idealized as a one-dimensional trumpet, whose cross section increases as the distance from the trachea increases. The transport of the aerosol is facilitated by the alveolar expansion, resulting in inhalation. The mass balance equation along with the complicated mechanisms of deposition including deposition by impaction, sedimentation and diffusion has been solved. The model has been validated using experimental data on total particle deposition and alveolar deposition over a range of particle sizes. The sensitivity deposition in the alveoli has been studied by performing a sensitivity analysis on the parameters determining the lung morphometry. From the sensitivity analysis it is concluded that the people with constricted distal airways are more susceptible to infection as well as can be targeted for efficient drug delivery. Thus the occurrence of secondary infection in patients with constricted lung dimensions could be explained. The sensitivity analysis also gives an important conclusion that the particles sizes which deposit in alveolar region of the lung in more concentration are the ones which are least sensitive to inter subject variability. Thus the drug which can be engineered in such particle sizes could result in maximum deposition at the targeted site. Based on the sensitivity co-efficient of deposition concentration of a particular particle size, the deviation of the given individual’s morphometry with respect to the base Weibel parameters is determined. Thus the deviation of the Weibel parameters can be used as a morphometric marker for treatment of the specific individual. © 2015 International Conference on Liquid Atomization and Spray Systems. All rights reserved.
About the journal
JournalICLASS 2015 - 13th International Conference on Liquid Atomization and Spray Systems
PublisherILASS � Europe, Institute for Liquid Atomization and Spray Systems
Open AccessNo