In recent climate change negotiations and debates, energy use pattern, efficiency and productivity cannot be overlooked and hence it is necessary to focus on these ascepts for Indian manufacturing industries. The objective of the paper is to estimate the transcendental logarithmic production function and analyse the relationship between energy intensity and total factor productivity (TFP). The estimation of TFP is based on four inputs model; labour, capital, material and energy. The findings suggest that labour and material inputs play major role as compared to the capital and energy input. Further, estimates suggest that age of the firm, export intensity and disembodied technology import are positively related to the TFP, where as ownership, energy intensity, embodied technology import and R&D intensity are negatively related to TFP of the Indian manufacturing industries. İn addition, energy efficient firms also found to have high levels of TFP. This implies the need for fostering energy efficiency at firm level in Indian Manufacturing.