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Therapeutic interventions using monotherapy versus combination therapy of aloe Vera and omega-3 fatty acids on gentamicin-initiated renal toxicity via attenuation of renal biomarkers
Maheshwari R.A., Kaur G., Sen D.B., Parmar G., Balaraman R., Seth A.K.,
Published in Association of Pharmaceutical Teachers of India
2021
Volume: 55
   
Issue: 1
Pages: s251 - s258
Abstract
Background and Aim: The proposed work was planned to evaluate the potential protective role of aqueous Aloe vera (AV) concentrate and/or Omega-3 fatty acids (O3FAs) against GM -initiated renal toxicity in rats. Materials and Methods: Thirty female Wistar-albino rats were distributed into five equivalent groups as follows: Normal control group, GM control group, GM + AV group (200 mg/kg, p.o.), GM + O3FAs group (100 mg/kg, p.o.), GM + AV + O3FAs group. All the treatments were administered for 10 days. Renal toxicity was initiated by intraperitoneal administration of GM (80 mg/kg/day) for last 5 days of test duration. Results: Noticeable rise in the levels of serum creatinine, urea, MDA, TNF-α, TGF-β1, Fibronectin and NGAL was seen alongside a significant decrese in the levels of serum albumin, total protein content and antioxidant enzymes, SOD, GSH, catalase in GM control group. Treatment with AV or O3FAs or AV + O3FAs exhibited a considerable reduction in serum creatinine, urea, MDA, TNF-α, TGF-β1, Fibronectin and NGAL levels and a rise in the levels of serum albumin, total protein and antioxidant enzymes. Conclusion: The study concluded the importance of AV and Omgea-3 fatty acids as effective nephroprotective agents. However, the combined treatment with AV and O3FAs showed similar beneficial effects as compared to monotherapy in mitigating adverse effects of GM-initiated renal toxicity. There was no significant difference observed in monotherapy as well as combination therapy. © 2021, Association of Pharmaceutical Teachers of India. All rights reserved.
About the journal
JournalIndian Journal of Pharmaceutical Education and Research
PublisherAssociation of Pharmaceutical Teachers of India
ISSN00195464
Open AccessNo