Cooling holes in turbine blades made of high-temperature materials such Titanium alloys are produced by laser processing. A priori knowledge on laser interaction with material will be useful in the selection of laser parameters in practice. In the present work, two-temperature model consisting of a set of coupled Partial Differential Equations in spatial and time domain is used to study ultra-short pulse laser-matter interaction. The model is solved using finite element simulation available in COMSOL Multi-physics software. The present approach is validated taking gold as bench mark material as results for 1D and 2D cases are already reported in literature. The simulation approach is then extended to titanium alloy (Ti6Al4V), the material under investigation in our present work. The simulation results are obtained for 2.00 mm thick Ti6Al4V using 2D axi-symmetric two-temperature model. In order to compare the results, single-shot laser ablation experiments are carried out at laser fluency ranging from 0.84 to 8.4 Jcm−2. A method has been proposed in this work for assessing the crater depth and diameter uniquely from the images of the ablated specimens obtained using laser scanning confocal microscope. The simulation and experimental results are presented and discussed. © 2018 Elsevier B.V.