In this work, density (ρ) and speed of sound (u) data were measured for aqueous solutions of two drugs namely Emtricitabine and Lamivudine in the various concentrations, m from (293.15 to 318.15) K and at 0.1 MPa pressure. The measured density and speed of sound data were used to calculate the apparent molar volume (Vφ) and the isentropic compressibility (κs), using Laplace-Newton's equation. The apparent molar volume at infinite dilutions (Vφ∞) of drugs has been evaluated from linear equation. The temperature dependence of apparent molar volume at infinite dilution (Vφ∞) can be expressed as the second-order polynomial equation, in turn apparent molar expansibility (Eφ∞) at infinite dilution was calculated. These parameters have been used to understand the effect of temperature on interactions between drugs and water. Moreover, the structure making and breaking ability of drugs are analyzed at experimental conditions. © 2015 Elsevier B.V.

Ramesh L. Gardas

Department Of Chemistry

Bharath Kumar Chennuri

Acoustic properties

Acoustic wave velocity

Ionic liquids

Laplace transforms

Polynomials

Solutions

Temperature distribution

Volume measurement

ANTI-HIV

Apparent molar volume

Effect of temperature

Experimental conditions

Isentropic compressibility

NEWTON EQUATION

SECOND-ORDER POLYNOMIAL EQUATIONS

temperature dependence

IONIC DRUGS

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

Journal of Molecular Liquids

The apparent molar volumes, Vϕ and apparent molar isentropic compressibilities, Ks,ϕ of three benzyldimethylammonium based protic ionic liquids, namely, benzyldimethylammonium acetate (BDMAA), benzyldimethylammonium propionate (BDMAP), and benzyldimethylammonium hexanoate (BDMAH) in water and ethanol have been determined at T=(293.15, 298.15, 303.15, 308.15, 313.15 and 318.15)K and at ambient pressure from density, ρ and speed of sound, u measurements. The Redlich-Mayer type of equation has been used to calculate the apparent molar volume, Vϕ∞ and apparent molar isentropic compressibility, Kϕ∞ at infinite dilution, and the corresponding empirical parameters (Sv, Bv, Sk and Bk). The negative magnitude of limiting volumetric slopes, Sv versus m1/2 for (BDMAA+ethanol) binary solutions, suggests that BDMAA-ethanol interactions are strong. Further, the change in thermodynamic properties of binary solutions in relation to the alternation in the anionic structural constitution of protic ionic liquids has also been evaluated. © 2014 Elsevier B.V.

Fluid Phase Equilibria

Apparent molar properties of benzyldimethylammonium based protic ionic liquids in water and ethanol at different temperatures

In this work, a new series of low viscous protic ionic liquids based on N-methylpyrrolidone cation and carboxylate anions with different chain length has been synthesized and characterized. Density, speed of sound and viscosity have been measured for these ionic liquids in the temperature range from 293.15 to 343.15. K. The density data have been fitted to linear equation as well as correlated with group contribution method developed by Gardas and Coutinho. From the density correlation, molecular volume data for cation and anion constituents of studied ionic liquids have been proposed. By using experimental density and speed of sound data, the isentropic compressibility, coefficient of thermal expansion, standard entropy, intermolecular free length and lattice energy have been calculated for studied ionic liquids. Viscosity data were correlated with the Vogel-Tammann-Fulcher equation. To understand the nature of the ionic liquids and structure-property relationship, the effect of anion alkyl chain length has been studied and correlated. Ionic liquids studied in this work are comparatively cheaper in price and can be promising in bio-macromolecule solubilization and other commercial fields. © 2014 Elsevier B.V.

Measurement and correlation for the thermophysical properties of novel pyrrolidonium ionic liquids: Effect of temperature and alkyl chain length on anion

Apparent molar volume (V2,φ) and apparent molar isentropic compressibility (Ks,2,φ) of diclofenac sodium salt (DSS) drug within the concentration range of (0.001 to 0.008) mol · kg-1 in (0.01, 0.03 and 0.05) mol · kg-1 aqueous glycine and l-proline solutions are computed from the experimental density (ρ) and speed of sound (u) values at T = (293.15 to 313.15) K and atmospheric pressure. Derived parameters such as partial molar properties, transfer partial molar properties, hydration numbers and Hepler's constant are computed from the data of V2,φ and Ks,2,φ. These parameters have been used to understand the effect of temperature on interactions between DSS drug and aqueous glycine/l-proline solution. Furthermore, the structure making and breaking ability of DSS drug in probed solutions are analysed at experimental conditions. © 2014 Elsevier Ltd. All rights reserved.

Journal of Chemical Thermodynamics

Effect of temperature on solvation behaviour of diclofenac sodium salt in aqueous glycine and l-proline solutions

The experimental density, ρ, speed of sound, u and viscosity, η values as a function of ionic liquid concentration, m for binary mixtures (benzyldimethylammonium propionate/benzyldimethylammonium hexanoate + N,N-dimethylformamide) were measured at T = 293.15 to 328.15 K and at atmospheric pressure. Apparent molar volumes, Vφ, and apparent molar isentropic compressibilities, Ks,φ, have been determined from the experimental densities and speed of sound and fitted to a Redlich-Mayer equation for the calculation of limiting parameters (Vφ∞and Kφ∞). The calculated Vφ∞and Kφ∞values indicate that ionic liquid-molecular solvent interactions are stronger for benzyldimethylammonium hexanoate (BDMAH) in DMF than the benzyldimethylammonium propionate (BDMAP) in DMF mixtures. The limiting apparent molar expansibilities, α at each temperature for both ionic liquids in DMF have positive values. The viscosity data have been analyzed using the Jones-Dole equation, and the derived parameters B and A have also been interpreted in terms of ion-solvent and ion-ion interactions. © 2014 Elsevier B.V.

Volumetric, acoustic and transport properties of binary mixtures of benzyldimethylammonium based ionic liquids with N,N-dimethylformamide at temperature from 293.15 to 328.15 K

Densities (ρ) and speeds of sound (u) of betaine hydrochloride (B.HCl) drug (0.01-0.06) mol kg-1 in (0.10, 0.20 and 0.30) mol kg-1aqueous NaCl and KCl solutions have been reported as a function of temperature at T = (293.15 -313.15) K and at atmospheric pressure. Using experimental data the apparent molar volume (V2,), partial molar volume (V2), transfer partial molar volume (ΔtV2), apparent molar isentropic compressibility (Ks,2,), partial molar isentropic compressibility (Ks,2), transfer partial molar isentropic compressibility (ΔtKs,2), partial molar expansion (E2) and Hepler's constant (2V2T2)P were calculated. Further, all these parameters are employed to understand the temperature and cosolute effects on B.HCl drug-solvent interactions. Cosphere overlap model is used to analyze the hydrophilic/ionic-ionic interactions in (B.HCl drug + NaCl/KCl + H2O) ternary mixture. The sign of Hepler's constant have been used to interpret the structure making or braking tendency of B.HCl drug in aqueous NaCl and KCl solutions at probed compositions and temperatures. © 2014 Elsevier B.V.

Thermochimica Acta

Volumetric properties of betaine hydrochloride drug in aqueous NaCl and KCl solutions at different temperatures

The structural effect on volumetric and acoustic properties of aqueous anti-HIV drugs (Emtricitabine and Lamivudine) at various temperatures

Journal	Data powered by TypesetJournal of Molecular Liquids
Publisher	Data powered by TypesetElsevier
ISSN	01677322
Open Access	No