Successful synthesis of unsymmetrical linear diarylheptanoids with syn-1,3-diol unit and their enantiomers have been achieved using acyl anion and Wittig olefination chemistry. The syn disposition of the two hydroxyl groups in the linear diarylheptanoids was achieved with the use of d-xylose as starting material. The synthesized compounds were tested for anti-proliferative activity on HeLa cells using MTT assay at 50 µm concentration. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Indrapal Singh Aidhen

Department Of Chemistry

Mukesh Doble

Department Of Biotechnology

Kasireddy Sudarshan

Govindaraj Perumal

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

European Journal of Organic Chemistry

A new route based on the use of acyl anion chemistry was developed for the synthesis of (+)-centrolobine and its analogues. Acid-catalyzed benzylic cation initiated cyclization was the key step in the stereoselective formation of the cis-2,6-disubstituted tetrahydropyran ring. The developed methodology was applied to the synthesis of (+)-centrolobine analogues containing electron-donating substituents in the aryl rings. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Synthesis of (+)-centrolobine and its analogues by using acyl anion chemistry

Helvetica Chimica Acta

An Efficient Stereoselective Total Synthesis of Bioactive (3R,5R)-1-(4-Hydroxyphenyl)-7-phenylheptane-3,5-diolviaAsymmetric Aldol Reaction

Synthesis

Catalytic Route to a Concise Stereoselective Synthesis of Cytotoxic (3S,5S)-1-(4-Hydroxyphenyl)-7-phenylheptane-3,5-diol and Its (3R,5S)-Isomer

CHEMICAL & PHARMACEUTICAL BULLETIN

Microbial Conversion of Curcumin into Colorless Hydroderivatives by the Endophytic Fungus Diaporthe sp. Associated with Curcuma longa

Bioorganic & Medicinal Chemistry

Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists

Synthesis of Unsymmetrical Linear Diarylheptanoids and their Enantiomers and Antiproliferative Activity Studies

Journal	Data powered by TypesetEuropean Journal of Organic Chemistry
Publisher	Data powered by TypesetWiley-VCH Verlag
ISSN	1434193X
Open Access	No