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Synthesis and characterization of chitosan-TiO2:Cu nanocomposite and their enhanced antimicrobial activity with visible light
Published in Elsevier B.V.
2016
PMID: 27693718
Volume: 148
   
Pages: 566 - 575
Abstract
In the present investigation, novel strategy for the preparation of hybrid nanocomposite containing organic polymer (Chitosan) and inorganic (TiO2:Cu) nanoparticles (NPs) has been developed and demonstrated its biomedical application. The sol–gel and ultra-sonication method assisted for the preparation of uniformly distributed Chitosan-TiO2:Cu (CS-CT) nanocomposite. The structural properties of prepared CS-CT nanocomposite were studied by XRD and FTIR techniques. The XPS was used to estimate elemental composition of the nanocomposite. Thermal properties were studied using TGA. TEM and SEM analysis showed the non-spherical nature of NPs with the average mean diameter 16 nm. The optical properties were analyzed with UV–vis diffuse reflectance spectroscopy to confirm optical absorption in the visible region of light. Where CS-CT showed 200% enhanced light mediated photocatalytic antimicrobial activity against microorganism (Escherichia coli and Staphylococcus aureus) as compared with control. The antimicrobial activity of CS-CT nanocomposite in presence of light is found to be enhanced than that of its components, this is due to synergistic effect of organic and inorganic material complimenting each other's activity. The [rad]OH radicals release studied by PL spectroscopy on the surface of nanocomposite was used to examine antibacterial activity. Cytotoxicity assessment of CS-CT on human fibroblast cells was performed by MTT assay. © 2016 Elsevier B.V.
About the journal
JournalData powered by TypesetColloids and Surfaces B: Biointerfaces
PublisherData powered by TypesetElsevier B.V.
ISSN09277765
Open AccessNo
Concepts (75)
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    Bacteria
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    Biocompatibility
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    Cell adhesion
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    Cell culture
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    Chitin
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    Chitosan
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    Electromagnetic wave absorption
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    Escherichia coli
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    Fourier transform infrared spectroscopy
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    Free radicals
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    Functional polymers
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    Light
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    Light absorption
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    Medical applications
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    Microorganisms
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    Optical properties
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    Organic polymers
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    Sols
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    Titanium dioxide
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    Anti-microbial activity
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    Biocompatible
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    Cell disruption
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    HYDROXYL RADICLE
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    MICROBIAL ADHESION
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    Nanocomposites
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    CHITOSAN TITANIUM DIOXIDE COPPER NANOCOMPOSITE
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    Hydroxyl radical
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    Nanocomposite
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    Unclassified drug
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    Antiinfective agent
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    Copper
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    Metal nanoparticle
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    Titanium
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    Antimicrobial activity
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    Article
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    Chemical composition
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    Controlled study
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    Cytotoxicity
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    Diffuse reflectance spectroscopy
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    Human
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    Human cell
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    Infrared spectroscopy
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    Mtt assay
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    Photocatalysis
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    Priority journal
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    Scanning electron microscopy
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    Staphylococcus aureus
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    Structure analysis
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    Synthesis
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    Thermogravimetry
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    Transmission electron microscopy
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    Ultraviolet spectroscopy
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    X ray diffraction
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    3t3 cell line
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    Animal
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    Cell survival
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    Chemistry
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    Drug effects
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    Mouse
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    Radiation response
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    Temperature
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    Ultrastructure
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    X ray photoelectron spectroscopy
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    Animals
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    Anti-bacterial agents
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    Cells, cultured
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    Humans
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    Metal nanoparticles
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    Mice
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    Microscopy, electron, scanning
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    Microscopy, electron, transmission
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    Nih 3t3 cells
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    Photoelectron spectroscopy
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    Spectroscopy, fourier transform infrared
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    X-ray diffraction