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Structure and dynamics of a dl-homocysteine functionalized fullerene-C60-gold nanocomposite: A femtomolar l-histidine sensor
Geevarghese Vadakken Jacob,
Published in Royal Society of Chemistry
2017
Volume: 5
   
Issue: 29
Pages: 5835 - 5844
Abstract
A functionalized fullerene-C60-thiol mediated gold nanocomposite was realized using dl-homocysteine as a bifunctional ligand. The nanocomposite was designed by following electronic structure calculations via the DFT formalism. The computed electrostatic potential profile and the electronic HOMO-LUMO energy gap implied enhanced electron transport across the nanocomposite skeleton. Accordingly, synthesis of the nanocomposite proceeded with the hydrophilic fullerene-C60 thiol derivative via in situ reduction of gold(iii), resulting in sterically full gold clusters bound to the fullerene-C60 core. Molecular dynamics simulations with the MM+ force field provided insight into the mode of interaction and direction of electron transfer in the nanocomposite-histidine ensemble. Subsequently, an electrochemical strategy for l-histidine sensing was proposed; the nanocomposite-modified glassy carbon electrode exhibited electrocatalytic activity towards l-histidine sensing, studied via cyclic and square wave voltammetry and impedance spectroscopy. A femtomolar l-histidine sensor, the first of its kind with orders of magnitude enhanced performance in its detection limit, linear range, sensitivity, stability and specificity, and free of interference, thus emerged. © 2017 The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetJournal of Materials Chemistry B
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN20507518
Open AccessNo
Concepts (21)
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    Amino acids
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    Carbon
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    Electrochemical impedance spectroscopy
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    Electrodes
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    Electron transport properties
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    Electronic structure
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    Fullerenes
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    Glass membrane electrodes
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    Gold
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    Gold compounds
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    Molecular dynamics
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    Voltammetry
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    Electrocatalytic activity
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    Electronic structure calculations
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    Electrostatic potentials
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    Impedance spectroscopy
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    Modified glassy carbon electrode
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    Molecular dynamics simulations
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    Square wave voltammetry
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    Structure and dynamics
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    Nanocomposites