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Strategies for targeted drug delivery in treatment of colon cancer: current trends and future perspectives
Gunasekaran Dharanivasan,
Published in Elsevier Ltd
2017
PMID: 28545838
Volume: 22
   
Issue: 8
Pages: 1224 - 1232
Abstract
Despite advances in treatment modalities, colon cancer (CC) is the third most common cause of cancer-related death worldwide. Subsequent unfavorable effects owing to toxicity of conventional drugs are a challenging problem associated with chemotherapy. There is noticeable concern toward site-specific/targeted delivery of chemotherapeutic drugs specifically to the affected site of the colon in a predictable and reproducible manner. However, the biggest challenge in successful drug targeting for the colon is avoidance of drug absorption and/or degradation in the upper gastrointestinal tract before the drug reaches the colon. Nanoparticles endowed with targeting abilities offer a novel approach for site-specific delivery of chemotherapeutic agents. The present review focuses on recent approaches for colon-specific drug delivery (CDDS) and aims to unveil the emerging possibilities and advances in the treatment of CC with CDDS. © 2017 Elsevier Ltd
About the journal
JournalData powered by TypesetDrug Discovery Today
PublisherData powered by TypesetElsevier Ltd
ISSN13596446
Open AccessNo
Concepts (28)
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    Carbon nanotube
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    Dendrimer
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    Metal oxide
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    Nanoparticle
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    Polymer
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    TELODENDRIMER
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    Unclassified drug
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    Antineoplastic agent
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    Nanomaterial
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    Cancer research
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    Chemical modification
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    COLON CANCER
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    Drug delivery system
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    Drug formulation
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    Drug targeting
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    Human
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    Medical literature
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    Review
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    Animal
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    Colon
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    COLON TUMOR
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    Metabolism
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    Animals
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    Antineoplastic agents
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    Colonic neoplasms
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    Drug delivery systems
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    Humans
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    Nanostructures