An environmentally benign route for the single-step synthesis of mesoporous sulfated titania is described by a seeding method using titanium oxysulfate as the titania source. The hydrolysis was performed in the presence of NaOH and seed under constant-volume conditions around 98 °C. The XPS and DRIFT spectra show the existence of a bridged bidentate sulfate complex on the surface of titania. The elimination of sulfur on heat treatment showed a characteristic change in mesoporosity, specific surface area, and crystallinity of the material. The transformation of sulfated titania to anatase was incomplete at 900 °C, showing a delay in crystallization due to the presence of sulfur. Studies on the thermal stability of the sulfated titania showed that the material obtained can be used for various applications at temperatures below 300 °C. The ammonia-TPD and catalytic performance studies of the sulfated titania samples showed the presence of strong acid sites. © 2009 American Chemical Society.