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Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods
Divya Ottoor
Published in
2010
PMID: 21134851
Volume: 60
   
Issue: 2
Pages: 141 - 152
Abstract
In the present work, four different spectrophotometric methods for simultaneous estimation of losartan potassium, amlodipine besilate and hydrochlorothiazide in raw materials and in formulations are described. Overlapped data was quantitatively resolved by using chemometric methods, classical least squares (CLS), multiple linear regression (MLR), principal component regression (PCR) and partial least squares (PLS). Calibrations were constructed using the absorption data matrix corresponding to the concentration data matrix, with measurements in the range of 230.5-350.4 nm (δλ = 0.1 nm) in their zero order spectra. The linearity range was found to be 8-40, 1-5 and 3-15 μg mL-1 for losartan potassium, amlodipine besilate and hydrochlorothiazide, respectively. The validity of the proposed methods was successfully assessed for analyses of drugs in the various prepared physical mixtures and in tablet formulations.
About the journal
JournalActa Pharmaceutica
ISSN13300075
Open AccessYes
Concepts (23)
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    AMLODIPINE BESYLATE
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    HYDROCHLOROTHIAZIDE
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    Losartan potassium
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    Article
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    Calibration
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    CHEMOMETRIC ANALYSIS
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    Human
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    MULTIPLE LINEAR REGRESSION ANALYSIS
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    Nonhuman
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    PARTIAL LEAST SQUARES REGRESSION
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    Principal component analysis
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    Regression analysis
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    Spectrophotometry
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    TABLET FORMULATION
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    AMLODIPINE
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    Chemistry, pharmaceutical
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    HYDROCHLOROTHIAZIDE
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    LEAST-SQUARES ANALYSIS
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    Linear models
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    LOSARTAN
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    Multivariate analysis
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    Spectrophotometry, ultraviolet
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    TABLETS