In an iterative inverse design of a turbine blade, choice of initial guess profile is crucial. As the pressure distribution is very sensitive to the leading and trailing edge shapes and the profile slope and curvature, a good initial guess profile will help in faster convergence. In this paper, the sensitivity of the pressure distribution is determined by carrying out numerical simulations with ANSYS Fluent 17.2 for the inviscid flow. The flow domain comprises of a two dimensional transonic turbine cascade. It consists of a turbine blade enclosed by inlet, outlet and periodic boundaries. Inlet total pressure, total temperature and inlet angle are given as the boundary conditions at the inlet and static pressure is imposed at the outlet boundary. The flow is solved for continuity, momentum and energy equations. Sensitivity of different parameters-leading edge thickness, trailing edge thickness, leading edge shape, inlet and outlet wedge angle on the pressure distribution is demonstrated for VKI blade cascade. It is found that the pressure side of the profile is less sensitive and that even a small variation in suction side of the profile geometry can affect the performance of the blade significantly.It is shown that, with the proposed methodology and sequence of steps, the final guess blade is quite close to the original blade. Copyright © 2019 ASME.